In addition to having one of the largest concentrations of world-class research institutions in the country, New York is a hub of activity in computational science, information technology, and cyberinfrastructure. Centers focused on developing New York's cyber-ecosystem include:

• CASE Center, Syracuse University
• Center for Advanced Computing (CAC), Cornell University
• Center for Advanced Information Technologies (CAIT), Binghamton University
• Center for Advanced Technology in Telecommunications (CATT), Polytechnic University
• Center for Advancing the Study of Cyberinfrastructure (CASCI), Rochester Institute of Technology
• Center for Computational Biology and Bioinformatics, Columbia University
  
• Center for Computational Research (CCR), University at Buffalo
• Center for Cyber Security, Stony Brook University
  
• Center for Digital Economy, New York University
  
• Center for Digital Research and Scholarship, Columbia University
• Center for International Earth Science Information Network (CIESIN), Columbia University
• Center for Technology in Government, University at Albany
• Center for Visual Computing, Stony Brook University
  
• Center of Excellence in Wireless and Information Technology, Stony Brook University
  
• Computational Center for Nanotechnology Innovation (CCNI), Rensselaer Polytechnic Institute
• Computational Science Center (CSC), Brookhaven National Laboratory
• Information Assurance Institute (IAI), Cornell University
  
• Institute for Computational Biomedicine, Cornell Weill Medical College
• Institute for Mathematics and Advanced Supercomputing, Polytechnic University
• Intelligent Information Systems Institute (IISI), Cornell University
  
• Scientific Computational Research Center (SCOREC), Rensselaer Polytechnic Institute
• Linux Technology Center, Binghamton University
  
• Stony Brook Center for Computational Science (SBCCS), Stony Brook University
• The Systems Assurance Institute, Syracuse University
• The Web Lab, Cornell University
  
• Wireless Communications and Networking Group, University of Rochester
• Wireless Internet Center for Advanced Technology (WICAT), Polytechnic University